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VIENNA -- Alzheimer's drug researchers served up a string of bad news at the International Conference on Alzheimer's Disease, presenting one failed trial after another.

None of these strategies tested--blocking amyloid, improving insulin sensitivity in the brain, or even doubling up on agents that improve synaptic signalling--was able to alter the steady rate of cognitive and functional decline in patients with mild to moderate Alzheimer's, also among the failures were the omega-3 fatty acid studies.

"We are again left to wonder whether clues from epidemiology are more related to delaying or protective factors rather than factors related to progression of established disease," said Dr. Samuel Gandy, Mount Sinai Professor of Alzheimer's Disease Research at Mount Sinai Medical Center in New York.

Instead of searching for the compound that will alter the so-far inevitable decline seen in Alzheimer's, the key will probably be preventing the disease from taking hold in the first place, he said in an interview.

Among the failures was a phase II placebo-controlled trial of rosiglitazone that showed no benefit on cognition in a group of 553 patients with mild to moderate Alzheimer's.

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The 24-week trial, sponsored by GlaxoSmithKlinc, randomized the patients (mean age 72 years) to placebo, a positive control group of donepezil 10 mg/day, or one of two rosiglitazone doses (2 mg or 8 mg daily). The extended-release formulation was an experimental one, and not the Food and Drug Administration-approved Avandia, Dr. Michael Gold said at the meeting.

The study examined each treatment's effect in the overall cohort, on those who were apolipoprotein E e4 (APOE e4) negative, and all subjects except those homozygous for the high-risk gene. The primary end points were changes in the Alzheimer's Disease Assessment Scale-cognitive domain (ADAS-cog) and Clinicians' Interview-Based Impression of Change plus Caregiver Input (CIBIC-plus).

At 24 weeks, neither of the rosiglitazone doses was significantly different from placebo in either cognitive assessment for any of the populations. But in the overall population and in the group that included everyone except the APOE e4 homozygous carriers, CIBIC scores were significantly better for those on donepezil than for those taking placebo.

Since that finding had not been adjusted for covariates, "I don't think it's anything we can hang our hats on," said Dr. Gold, global clinical vice president of neurology at GlaxoSmithKline, Durham, N.C.

Dr. Gordon Wilcock reported another failed phase III trial for tarenflurbil, this one conducted in the United States, Canada, and Western Europe. In 2008, tarenflurbil, a selective amyloid-lowering agent, failed its highly anticipated phase III U.S. trial.

"With two failed phase III trials, tarenflurbil has killed itself off completely," Dr. Wilcock, of the University of Oxford (England), said at the meeting.

Tarenflurbil was the first gamma secretase modulator to be tested in a phase III trial. This class of drug is thought to reduce the levels of toxic amyloid beta ([AB.sub.42]) in the brain by changing the point at which the enzyme gamma secretase cuts the amyloid precursor lace wigs protein, shifting the ratio to less of the toxic [AB.sub.42] and more of the less-toxic [AB.sub.40].

The most recent trial failed to show statistically signi
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She Laughs at Your Jokes

A nice girl wants you to feel at ease Chloe Handbags. so she'll try to do small things to make you feel comfortable. Even if nerves get the better of you (or what you say isn't remotely humorous) she'll be understanding. In short Fleur de lis Handbags . she won't scowl at you for forgetting the punch line of a joke or stumbling when you try and tell a story. She will laugh politely and encourage you to go on.

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A nice girl trusts that when a guy takes her out IWC Watches . he will do his best to make sure the date goes smoothly. So if that fabulous restaurant he suggested is packed. she'll easily adapt to a change of plan. She doesn't expect a guy to bring flowers and poems on the first date. However. she knows first dates aren't always perfect and that's okay.

She Stays Focused on You Alone

Even if a girl desperately wants to go home and read a book. she knows it's rude to look around the restaurant or coffee shop for an exit. If she's pressed for time Makeup Mirrors Handbags . she won't look continually at her watch. Instead. she'll keep her eyes focused on you and will not make you feel as if you are wasting her time.

She Doesn't Expect a Free Meal

There seems to be a lot of argument among singles today in regards to who should pay for the check. The answer is this: A nice girl should offer to pay for her meal or coffee Tote Handbags. and if it's a first date a guy should refuse her offer and pick up the tab. Quality women don't expect to be waited on or to get everything in life for free. That attitude also applies to their dating life. So when a guy does make the move to treat his gal. it makes that much more of than impression.

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VIRGINIA BEACH - Constantine J. "Gus" Karides, 81, departed this life peacefully Jan. 14, 2008, in the comfort of his home with loving family by his side. Gus was a caring, unselfish man whose positive messages and cheery personality touched his family and friends in many ways.

Born in Altoona, Pa., of Greek emigrants, Gus graduated from Albany High School in 1944 before enlisting in the Navy to serve during World War II and became a part of what many consider the "Greatest Generation watches x Ever." He married his high school sweetheart, Chrisoula "Goldie" (Mafilios) Karides in 1947. During their more than 60 years of marriage, Gus' love for his wife was never more evident than during the final days of his life.

Gus had a successful career as a businessman and entrepreneur. He and his brother George opened the Strand Fruit Market in Albany, N.Y., and in 1968 they came to Virginia and founded Mr. Jim's Jumbo Submarine Sandwiches and were regional franchisors for convenient food marts. He was a member of Thalia United Methodist Church and was a leader in the church men's group and Seekers Sunday School.

Gus was predeceased by his parents, James K. Karides and Vasiliki Kasselides; a sister, Harriet J. Amanatides; and brother, George J. Karides. He is survived by his wife, Chrisoula Mafilios Karides; his daughter, Lillian K. Hingson and her husband Randal Hingson of Morehead City, N.C.; his daughter, Diana J. Martin and her husband James Martin of Charlotte, N.C.; his son, James P. Karides and his wife Guzin N. Karides of Virginia Beach; 10 grandchildren, Constantine C. Hingson, R. Peter Hingson, Christina B. Hingson, Margaret A. Hudson, Sarah C. Hudson, Eric W. Hudson, Rachel J. Hudson, Adam J. Karides, J. Baodan Collins and Neos J. Karides; his sisters, Pauline K. Anastas, Helen Trivelas and friend Raymond DeCecco and Anna K. Mafilios and her husband Achilles S. Mafilios; his lifelong friend, George W. Cooper and many extended family members.

A celebration of Gus' life will be held Friday at 1 p.m. in Thalia United Methodist Church, 4321 Virginia Beach Blvd., Virginia Beach. Friends may join the family today from 5 to 7:30 p.m. in Thalia United Methodist Church. In Movado Serenade lieu of flowers, contributions in Gus' memory may be made to Thalia United Methodist Church Building Fund, Men's Group or Seekers Sunday School Class.

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Constantine Metal Resources Ltd. (TSX VENTURE: CEM) (the "Company") is pleased to announce partial analytical results for 1 drill hole at the ongoing 2007 drilling program on its polymetallic massive sulphide Palmer project near Haines, Alaska. The 2007 Palmer drilling program started in late July and to date more than 6000 ft (greater than 1800m) of drilling has been completed in 6 holes. Partial assay results have been received for hole CMR07-07; all other assay results are pending.

Hole CMR07-07 intersected 45.90 ft (14.0m) of 3.79% copper, 7.24% zinc, 0.37 g/t gold, 47 g/t silver. The intersection can be divided into an upper zinc zone; 14.30 ft (4.4m) - 13.60% zinc, 0.65% copper, 0.15 g/t gold, 18 g/t silver and a contiguous underlying copper zone; 31.60 ft (9.6m) 5.22% copper, 4.36% zinc, 0.47 g/t gold, 60 g/t silver. The estimated true width of the intersection is approximately 85-90% of the core length. The intersection is on the Glacier Creek prospect and is located in the footwall to the RW Zone at base of the RW rhyolite. It represents a third stacked high grade mineralized horizon (RW2) that can be tested with surface drilling.

The CMR07-07 high grade intersection is located 230 ft (70m) west of the 2006 intersection in CMR06-01 (16.8 ft (5.12m) of 10.86% zinc, 0.13% Pb, 0.23% copper, 0.13 g/t gold and 44.4 g/t silver) and about 230 ft (70m) east of a 36 ft (11m) interval of rhyolite hosted massive pyrite stringers at the base of the RW horizon (0.81% zinc and 0.15% copper) in CMR06-03. Two drill holes were completed from the CMR07-07 drill site in 2007. The second hole (CMR07-08) intersected the same mineralized watches m horizon as CMR07-07, in an 83 ft (25.3m) wide zone of leached barite and oxidized sulphides. This intercept is approximately 165 ft (50 m) updip from the CMR07-07 intercept towards the oxidized surface exposure of the zone. Assays for the CMR-07-08 intercept are pending.

The RW and the RW2 zones are separated by the RW rhyolite that varies from 0 to a maximum indicated thickness of 180 ft (55m). In the absence of the RW rhyolite, the RW and RW2 zones become a single sulphide horizon which appears to be the case with the 2006 intersection in CMR06-01. The RW and RW2 zones remain open to the east and west and down dip to the northwest and northeast.

At the Cap prospect target, two holes (aggregate of 2204 ft) were drilled to test for strike extensions and metal zonation relative to historic (pre-Constantine) drill intercepts of 76.1 ft (23.2m) in Cap-01 of 134 ppm silver (3.91 oz/t), 0.24% zinc, 0.16% Pb and 297.2 ft (90.6m) in RMC98-01 of 31 ppm silver (0.90 oz/t), that includes 35.8 ft (10.9m) of 62 ppm silver (1.81 oz/t), 0.19 ppm gold, 0.21% zinc. The Constantine holes (CMR07-04 and CMR07-05) indicate continuity of mineralization and alteration.

The remaining four, 2007 holes completed to date (including CMR07-07 and CMR07-08 discussed above) are located at the Glacier Creek prospect, testing the RW (and RW2), Main and South Wall targets. The drill is currently operating at a lower elevation drill site, 1640 ft (500m) east of the CMR07-07 drill pad where it is testing the RW-RW2, Main zone and South Wall horizons. One hole has been completed at this site (CMR07-09) and a second hole (CMR07-10) is in progress. CMR07-10 is expected to be the final hole of the 2007 drill program.

Garfield MacVeigh, President and CEO, commented, "The mineralized zones encountered to date continue to demonstrate the exciting potential of the project. The latest holes have indicated the presence of a thick zone of mineralization with good grade and continue to build and confirm the geological interpretation. There are many obvious step-out hol
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SOMEONE should perhaps buy our new Prime Minister a cowboy hat, blue jeans and a good holster. Nothing to do with the unkind taunts about the Brokeback Coalition.

But because David Cameron Flat leather sandals has developed a rather endearing habit of shooting from the hip.

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In the firing line in the last fortnight have been Israel for turning Gaza into a "prison camp". And then Pakistan, which he virtually accused of exporting terror.

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Whether they're deserving targets or not, he should be given credit for saying what he thinks and then standing by his words.

But last week he took aim and pulled the trigger, only to see the pistol backfire.

I am not talking about his gaffe about a nuclear Iran, because that is what it was... a mistake, a slip of the tongue.

No, more incendiary domestically were his remarks about council housing.

He was proposing fixedterm lettings of five or 10 years instead of the current promise that a council home is for life.

His point was that when family cicumstances change or children leave home, tenants could move to smaller accommodation freeing up the bigger house for those in greater need.

Critics have been quick to point out that it flies in the face of everything the Tories have been saying about the socalled Big Society and tackling petty crime.

The Conservatives have been looking to communities to start helping themselves more, to try to stamp out yobbish behaviour and to improve their own neighbourhoods.

But many of the real social problems are on council estates and to improve things you need families to feel they belong, to feel they have security of tenure and to believe they're making a home for life.

Only then will they feel a sense of community and be able to get together to act.

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If tenancies are often changing, with different people moving in and out and the population of an estate is transient, then the chances are it will have the opposite effect and lead to ghettoes and more problems.

Housing experts say the estates with the highest levels of social problems tend to have an unusually high turnover of tenants.

Housing swaps, where council tenants will be able to switch their homes with others who live elsewhere, is a policy that does work. But Mr Cameron's proposals take things a good deal further.

In short, the idea needs thinking through. The obvious answer is to build more social housing. But the spending cuts make that very unlikely.

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The Lib Dems are already up in arms and disowning the policy.

They say no such plan was ever discussed by the coalition. And it is just Christian louboutin flats the sort of issue that will expose the divisions everyone knows are there. David Cameron's interests at the moment lie in keeping the Government together. So now is probably not the time to pick a fight over an issue as delicate as social housing.

He should carry on shooting from the hip. It's quiChristian Louboutin Shoes
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